BREAK Free From Forever Meds
View Protocol Understand the ScienceBREAK stands for "Barrier Repair & Epithelial Activation Kit". It is an 8-12 week treatment protocol for ulcerative colitis, scientifically designed to target and restore the underlying mechanisms that drive chronic, recurring disease. Rather than relying on lifelong pharmaceuticals for symptom control, BREAK aims to promote long-term healing, regeneration, and sustained remission - without dependence on prescription drugs.
Ulcerative colitis develops when the colon's natural repair mechanisms fail, creating self-reinforcing cycles of inflammation and barrier dysfunction.
Initial damage from infection, antibiotics, emulsifiers, or NSAIDs leads to goblet cell loss
Increased permeability allows microbial antigens to flood the lamina propria
TLR activation triggers TNF-α, IL-6, IL-13 cascade, blocking regeneration
Notch pathway imbalance stalls goblet cell renewal
Dysbiosis and oxidative stress starve stem cells of energy
Treg/IL-10 dysfunction prevents resolution, making inflammation chronic
Lasting recovery requires breaking all pathological cycles simultaneously, giving the body the conditions it needs to heal.
Ulcerative colitis involves a self-reinforcing loop of epithelial damage, inflammation, dysbiosis, and metabolic stress. Standard treatments often interrupt one part of this cycle-usually inflammation-while leaving others untouched.
Anti-TNF drugs reduce cytokine-driven inflammation but don't restore the barrier or microbiome. Steroids suppress symptoms but don't promote healing and may worsen microbial balance. 5-ASAs dampen NF-κB signaling but don't address crypt dysfunction or butyrate depletion. Anti-integrins like vedolizumab reduce immune cell traffic but can't regenerate goblet cells or reverse redox stress.
As a result, symptom relief is often temporary. Without addressing the full regenerative and microbial deficits, long-term remission remains unstable.
This protocol targets multiple failure nodes simultaneously to break the cycle
| Target | Compound | Key Action |
|---|---|---|
| Cytokine Suppression | Andrographis paniculata | ↓ TNF-α, IL-6, IL-131,2 |
| IL-22 Restoration | Diindolylmethane (DIM) | AhR agonist → ↑IL-22, Treg18 |
| Notch Inhibition | EGCG | γ-Secretase block, antioxidant8,17 |
| Stem Cell Support | Tributyrin | ↑Tight junctions, redox reset12 |
| Barrier Repair | Curcumin BCM-95® | NF-κB/STAT3 block3,11 |
| Immune Tolerance | B. longum Probiotic | ↑IL-10, Treg activation9 |
Peer-reviewed studies supporting our protocol components