How It Forms
- Initial epithelial damage breaches barrier
- Luminal antigens activate NF-κB
- Sustained TNF-α and IL-6 production
- Cytokines prevent barrier repair
Self-Reinforcement
- TNF-α disrupts tight junctions
- Increased permeability → more antigen influx
- More NF-κB activation → more cytokines
- Barrier never heals → inflammation persists
Breaking This Cycle
BREAK Protocol Interventions
- Andrographis - Inhibits NF-κB and JAK/STAT
- Curcumin BCM-95 - Modulates cytokine pathways
- Tributyrin - Strengthens barrier function