Immune-Tolerance Cycle

Prevents normal resolution and maintains chronic activation

How It Forms

Chronic inflammation exhausts Tregs
IL-10 production becomes insufficient
Th17 cells dominate
Resolution mechanisms fail

Self-Reinforcement

Th17 produces IL-17 and IL-23
These cytokines suppress Tregs
Without Tregs, no resolution
Immune system stays activated

Clinical Relevance

This cycle explains why UC patients often can't achieve lasting remission even when inflammation temporarily decreases. The immune system has "forgotten" how to turn off.

Breaking This Cycle

BREAK Protocol Interventions

B. longum - Expands Tregs and increases IL-10
DIM - Promotes regulatory T cell development
Curcumin BCM-95 - Suppresses Th1/Th17 polarization

Back to Cycle 4 Continue to Conclusion